- RESEARCH BRIEFINGS
Rapid epidemic expansion of the SARS-CoV-2 Omicron variant in southern Africa
- Raquel Viana
0
, - Sikhulile Moyo
1
, - Daniel G. Amoako
2
, - Houriiyah Tegally
3
, - Cathrine Scheepers
4
, - Christian L. Althaus
5
, - Ugochukwu J. Anyaneji
6
, - Phillip A. Bester
7
, - Maciej F. Boni
8
, - Mohammed Chand
9
, - Wonderful T. Choga
10
, - Rachel Colquhoun
11
, - Michaela Davids
12
, - Koen Deforche
13
, - Deelan Doolabh
14
, - Louis du Plessis
15
, - Susan Engelbrecht
16
, - Josie Everatt
17
, - Jennifer Giandhari
18
, - Marta Giovanetti
19
, - Diana Hardie
20
, - Verity Hill
21
, - Nei-Yuan Hsiao
22
, - Arash Iranzadeh
23
, - Arshad Ismail
24
, - Charity Joseph
25
, - Rageema Joseph
26
, - Legodile Koopile
27
, - Sergei L. Kosakovsky Pond
28
, - Moritz U. G. Kraemer
29
, - Lesego Kuate-Lere
30
, - Oluwakemi Laguda-Akingba
31
, - Onalethatha Lesetedi-Mafoko
32
, - Richard J. Lessells
33
, - Shahin Lockman
34
, - Alexander G. Lucaci
35
, - Arisha Maharaj
36
, - Boitshoko Mahlangu
37
, - Tongai Maponga
38
, - Kamela Mahlakwane
39
, - Zinhle Makatini
40
, - Gert Marais
41
, - Dorcas Maruapula
42
, - Kereng Masupu
43
, - Mogomotsi Matshaba
44
, - Simnikiwe Mayaphi
45
, - Nokuzola Mbhele
46
, - Mpaphi B. Mbulawa
47
, - Adriano Mendes
48
, - Koleka Mlisana
49
, - Anele Mnguni
50
, - Thabo Mohale
51
, - Monika Moir
52
, - Kgomotso Moruisi
53
, - Mosepele Mosepele
54
, - Gerald Motsatsi
55
, - Modisa S. Motswaledi
56
, - Thongbotho Mphoyakgosi
57
, - Nokukhanya Msomi
58
, - Peter N. Mwangi
59
, - Yeshnee Naidoo
60
, - Noxolo Ntuli
61
, - Martin Nyaga
62
, - Lucier Olubayo
63
, - Sureshnee Pillay
64
, - Botshelo Radibe
65
, - Yajna Ramphal
66
, - Upasana Ramphal
67
, - James E. San
68
, - Lesley Scott
69
, - Roger Shapiro
70
, - Lavanya Singh
71
, - Pamela Smith-Lawrence
72
, - Wendy Stevens
73
, - Amy Strydom
74
, - Kathleen Subramoney
75
, - Naume Tebeila
76
, - Derek Tshiabuila
77
, - Joseph Tsui
78
, - Stephanie van Wyk
79
, - Steven Weaver
80
, - Constantinos K. Wibmer
81
, - Eduan Wilkinson
82
, - Nicole Wolter
83
, - Alexander E. Zarebski
84
, - Boitumelo Zuze
85
, - Dominique Goedhals
86
, - Wolfgang Preiser
87
, - Florette Treurnicht
88
, - Marietje Venter
89
, - Carolyn Williamson
90
, - Oliver G. Pybus
91
, - Jinal Bhiman
92
, - Allison Glass
93
, - Darren P. Martin
94
, - Andrew Rambaut
95
, - Simani Gaseitsiwe
96
, - Anne von Gottberg
97
& - Tulio de Oliveira
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Raquel Viana
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Lancet Laboratories, Johannesburg, South Africa.
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Sikhulile Moyo
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Botswana Harvard AIDS Institute Partnership, Botswana Harvard HIV Reference Laboratory, Gaborone, Botswana. Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Botswana Presidential COVID-19 Taskforce, Gaborone, Botswana.
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Daniel G. Amoako
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National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa.
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Houriiyah Tegally
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KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
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Cathrine Scheepers
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National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa. South African Medical Research Council Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
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Christian L. Althaus
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Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
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Ugochukwu J. Anyaneji
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KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
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Phillip A. Bester
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Division of Virology, National Health Laboratory Service, Bloemfontein, South Africa. Division of Virology, University of the Free State, Bloemfontein, South Africa.
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Maciej F. Boni
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Center for Infectious Disease Dynamics, Department of Biology, Pennsylvania State University, University Park, PA, USA.
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Mohammed Chand
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Diagnofirm Medical Laboratories, Gaborone, Botswana.
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Wonderful T. Choga
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Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
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Rachel Colquhoun
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Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK.
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Michaela Davids
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Zoonotic Arbo and Respiratory Virus Program, Centre for Viral Zoonoses, Department of Medical Virology, University of Pretoria, Pretoria, South Africa.
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Koen Deforche
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Emweb bv, Herent, Belgium.
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Deelan Doolabh
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Division of Medical Virology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
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Louis du Plessis
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Department of Zoology, University of Oxford, Oxford, UK. Department of Biosystems Science and Engineering, ETH Zurich, Switzerland
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Susan Engelbrecht
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Division of Medical Virology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town, South Africa.
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Josie Everatt
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National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa.
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Jennifer Giandhari
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KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
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Marta Giovanetti
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Laboratorio de Flavivirus, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil. Laboratório de Genética Celular e Molecular, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
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Diana Hardie
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Division of Medical Virology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa. Division of Virology, NHLS Groote Schuur Laboratory, Cape Town, South Africa.
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Verity Hill
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Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK.
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Nei-Yuan Hsiao
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Division of Medical Virology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa. Division of Virology, NHLS Groote Schuur Laboratory, Cape Town, South Africa. Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa).
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Arash Iranzadeh
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Division of Computational Biology, Faculty of Health Sciences, University of Cape Town.
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Arshad Ismail
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National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa.
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Charity Joseph
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Diagnofirm Medical Laboratories, Gaborone, Botswana.
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Rageema Joseph
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Division of Medical Virology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
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Legodile Koopile
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Botswana Harvard AIDS Institute Partnership, Botswana Harvard HIV Reference Laboratory, Gaborone, Botswana.
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Sergei L. Kosakovsky Pond
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Institute for Genomics and Evolutionary Medicine, Department of Biology, Temple University, Pennsylvania, USA.
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Moritz U. G. Kraemer
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Department of Zoology, University of Oxford, Oxford, UK.
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Lesego Kuate-Lere
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Health Services Management, Ministry of Health and Wellness, Gaborone, Botswana.
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Oluwakemi Laguda-Akingba
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NHLS Port Elizabeth Laboratory, Port Elizabeth, South Africa. Faculty of Health Sciences, Walter Sisulu University, Eastern Cape, South Africa.
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Onalethatha Lesetedi-Mafoko
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Public Health Department, Integrated Disease Surveillance and Response, Ministry of Health and Wellness, Gaborone, Botswana.
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Richard J. Lessells
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KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
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Shahin Lockman
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Botswana Harvard AIDS Institute Partnership, Botswana Harvard HIV Reference Laboratory, Gaborone, Botswana. Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
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Alexander G. Lucaci
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Institute for Genomics and Evolutionary Medicine, Department of Biology, Temple University, Pennsylvania, USA.
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Arisha Maharaj
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KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
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Boitshoko Mahlangu
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National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa.
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Tongai Maponga
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Division of Medical Virology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town, South Africa.
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Kamela Mahlakwane
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Division of Medical Virology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town, South Africa. NHLS Tygerberg Laboratory, Tygerberg, Cape Town, South Africa.
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Zinhle Makatini
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Department of Virology, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa.
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Gert Marais
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Division of Medical Virology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa. Division of Virology, NHLS Groote Schuur Laboratory, Cape Town, South Africa.
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Dorcas Maruapula
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Botswana Harvard AIDS Institute Partnership, Botswana Harvard HIV Reference Laboratory, Gaborone, Botswana.
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Kereng Masupu
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Botswana Presidential COVID-19 Taskforce, Gaborone, Botswana.
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Mogomotsi Matshaba
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Botswana Presidential COVID-19 Taskforce, Gaborone, Botswana. Botswana-Baylor Children’s Clinical Centre of Excellence. Baylor College of Medicine, Houston, Texas, USA.
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Simnikiwe Mayaphi
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Department of Medical Virology, University of Pretoria, Pretoria, South Africa.
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Nokuzola Mbhele
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Division of Medical Virology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
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Mpaphi B. Mbulawa
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National Health Laboratory, Health Services Management, Ministry of Health and Wellness, Gaborone, Botswana.
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Adriano Mendes
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Zoonotic Arbo and Respiratory Virus Program, Centre for Viral Zoonoses, Department of Medical Virology, University of Pretoria, Pretoria, South Africa.
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Koleka Mlisana
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National Health Laboratory Service (NHLS), Johannesburg, South Africa. Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.
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Anele Mnguni
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National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa.
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Thabo Mohale
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National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa.
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Monika Moir
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Centre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch, South Africa.
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Kgomotso Moruisi
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Health Services Management, Ministry of Health and Wellness, Gaborone, Botswana.
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Mosepele Mosepele
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Botswana Presidential COVID-19 Taskforce, Gaborone, Botswana. Department of Medicine, Faculty of Medicine, University of Botswana, Gaborone, Botswana.
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Gerald Motsatsi
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National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa.
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Modisa S. Motswaledi
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Botswana Presidential COVID-19 Taskforce, Gaborone, Botswana. Department of Medical Laboratory Sciences, School of Allied Health Professions, Faculty of Health Sciences, University of Botswana, Gaborone, Botswana.
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Thongbotho Mphoyakgosi
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National Health Laboratory, Health Services Management, Ministry of Health and Wellness, Gaborone, Botswana.
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Nokukhanya Msomi
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Discipline of Virology, School of Laboratory Medicine and Medical Sciences and National Health Laboratory Service (NHLS), University of KwaZulu–Natal, Durban, South Africa.
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Peter N. Mwangi
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Division of Virology, University of the Free State, Bloemfontein, South Africa. Next Generation Sequencing Unit, Division of Virology, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa.
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Yeshnee Naidoo
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KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
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Noxolo Ntuli
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National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa.
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Martin Nyaga
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Division of Virology, University of the Free State, Bloemfontein, South Africa. Next Generation Sequencing Unit, Division of Virology, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa.
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Lucier Olubayo
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Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa). Division of Computational Biology, Faculty of Health Sciences, University of Cape Town.
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Sureshnee Pillay
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KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
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Botshelo Radibe
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Botswana Harvard AIDS Institute Partnership, Botswana Harvard HIV Reference Laboratory, Gaborone, Botswana.
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Yajna Ramphal
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KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
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Upasana Ramphal
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KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
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James E. San
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KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
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Lesley Scott
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Department of Molecular Medicine and Haematology, University of the Witwatersrand, Johannesburg, South Africa.
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Roger Shapiro
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Botswana Harvard AIDS Institute Partnership, Botswana Harvard HIV Reference Laboratory, Gaborone, Botswana. Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
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Lavanya Singh
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KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
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Pamela Smith-Lawrence
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Health Services Management, Ministry of Health and Wellness, Gaborone, Botswana.
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Wendy Stevens
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Department of Molecular Medicine and Haematology, University of the Witwatersrand, Johannesburg, South Africa.
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Amy Strydom
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Zoonotic Arbo and Respiratory Virus Program, Centre for Viral Zoonoses, Department of Medical Virology, University of Pretoria, Pretoria, South Africa.
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Kathleen Subramoney
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Department of Virology, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa.
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Naume Tebeila
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National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa.
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Derek Tshiabuila
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KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
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Joseph Tsui
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Department of Zoology, University of Oxford, Oxford, UK.
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Stephanie van Wyk
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Centre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch, South Africa.
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Steven Weaver
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Institute for Genomics and Evolutionary Medicine, Department of Biology, Temple University, Pennsylvania, USA.
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Constantinos K. Wibmer
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National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa.
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Eduan Wilkinson
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Centre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch, South Africa.
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Nicole Wolter
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National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa. School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
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Alexander E. Zarebski
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Department of Zoology, University of Oxford, Oxford, UK.
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Boitumelo Zuze
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Botswana Harvard AIDS Institute Partnership, Botswana Harvard HIV Reference Laboratory, Gaborone, Botswana.
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Dominique Goedhals
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Division of Virology, University of the Free State, Bloemfontein, South Africa. PathCare Vermaak, Pretoria, South Africa.
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Wolfgang Preiser
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Division of Medical Virology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town, South Africa. NHLS Tygerberg Laboratory, Tygerberg, Cape Town, South Africa.
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Florette Treurnicht
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Department of Virology, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa.
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Marietje Venter
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Zoonotic Arbo and Respiratory Virus Program, Centre for Viral Zoonoses, Department of Medical Virology, University of Pretoria, Pretoria, South Africa.
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Carolyn Williamson
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ivision of Medical Virology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa. Division of Virology, NHLS Groote Schuur Laboratory, Cape Town, South Africa. Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa). Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
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Oliver G. Pybus
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Department of Zoology, University of Oxford, Oxford, UK.
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Jinal Bhiman
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National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa.
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Allison Glass
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Lancet Laboratories, Johannesburg, South Africa. Department of Molecular Pathology, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
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Darren P. Martin
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Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa). Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
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Andrew Rambaut
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Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK.
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Simani Gaseitsiwe
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Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Botswana Presidential COVID-19 Taskforce, Gaborone, Botswana.
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Anne von Gottberg
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National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa. School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
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KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa. Centre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch, South Africa. Department of Global Health, University of Washington, Seattle, WA, USA.
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Advance article preview
This manuscript has been peer reviewed and accepted for publication in Nature and is provided in this format here as a response to the exceptional public-health crisis. This accepted manuscript will continue through the processes of copy editing and formatting to publication of a finalized version of record on nature.com. Please note there may be errors present in this version, which may affect the content, and all legal disclaimers apply.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic in southern Africa has been characterised by three distinct waves. The first was associated with a mix of SARS-CoV-2 lineages, whilst the second and third waves were driven by the Beta and Delta variants, respectively1–3. In November 2021, genomic surveillance teams in South Africa and Botswana detected a new SARS-CoV-2 variant associated with a rapid resurgence of infections in Gauteng Province, South Africa. Within three days of the first genome being uploaded, it was designated a variant of concern (Omicron) by the World Health Organization and, within three weeks, had been identified in 87 countries. The Omicron variant is exceptional for carrying over 30 mutations in the spike glycoprotein, predicted to influence antibody neutralization and spike function4. Here, we describe the genomic profile and early transmission dynamics of Omicron, highlighting the rapid spread in regions with high levels of population immunity.
doi: https://doi.org/10.1038/d41586-021-03832-5
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Animal Care Technician
Oklahoma Medical Research Foundation (OMRF)
Oklahoma City, United States
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Animal Support Technician
Oklahoma Medical Research Foundation (OMRF)
Oklahoma City, United States
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Postdoctoral Fellow in Legume Proteomics
The University of British Columbia (UBC)
Vancouver, Canada